0.1M Sodium Nitrate Preparation and Standardization

0.1M Sodium Nitrate Preparation and Standardization of volumetric solution as per USP:

Preparation of 0.1M Sodium Nitrate:

• Take 1000ml of volumetric flask or bottle.
• Add 6.9g of sodium nitrate into it.
• Dissolve the sodium nitrate in sufficient water and dilute up to 1000lml of water.

Standardization of 0.1M Sodium Nitrate:

• Dry the USP Sulfanilamine RS at 105°C for 3hrs.
• Weigh about 500mg/0.5g of USP Sulfanilamine RS.
• Transfer into the suitable beaker.
• Add 20ml of hydrochloric acid and 50ml of water.
• Stir the solution until dissolved and cool to 15°C.
• Maintaining temperature at about 15°C, titrate slowly with sodium nitrate solution.
• Determine the end-point electrometrically, using a platinum-calomel electrode or platinum-platinum electrode.

17.22mg of sulfanilamide is equivalent to 1ml of 0.1M sodium nitrate.

Calculation formula of 0.1M Sodium Nitrate:

Molarity of Sodium Nitrate = W / 172.2 x V

Safety Instructions of Sodium Nitrate:

• Sodium Nitrate is very hazardous in case of eye contact (Irritant), ingestion, or inhalation.
• Hazardous in case of skin contact.
• Prolonged exposure may result in skin burns and ulcerations.
• Overexposure by inhalation may cause respiratory irritation.
• Severe over-exposure can result in death.
• Inflammation of the eye is characterized by redness, watering, and itching.

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• Why is Data integrity important in pharma?

Refer YT Channel: Pharmabeejpro