What are the UPLC advantages over HPLC in pharma

UPLC Advantages Over HPLC:

Even though the working principle of UPLC and HPLC are the same but UPLC is a more advanced separation technique as compared to HPLC.

Let’s understand the what are the UPLC advantages over HPLC?

  1. Speed
  2. Resolution
  3. Specificity
  4. Time and Cost Effective

Speed:

  1. Reduction in solvent consumption
  2. Increased sample throughout

Resolution:

  1. The enhanced sensitivity allows lower levels of analysis
  2. With smaller particle sizes and good peak separation, you can analyze samples with multiple analytes in difficult matrices

Specificity:

Detailed and sharp peaks – better peak separation

Time and Cost Effective:

  1. Operating at a higher pressure
  2. Not just reducing solvent consumption, but reducing storage and disposal as well
  3. A shorter run time, improved sensitivity, and selectivity of the analytes allow for a higher sample throughout
UPLC Advantages Over HPLC
HPLC vs UPLC

Also Read:

Refer YT Channel: Pharmabeej

Leave a Comment

two + 16 =