Principle of Quality control instruments in Pharma lab
In the pharmaceutical industry, multiple instruments are used. In this article, we are going to explain the Principles of Quality Control instruments in the pharma lab.
In the pharma industry number of instruments are used to produce, analyze, and pack the drug product. Some of the instruments we are going to learn today.
Principle of Quality Control instruments:
Here are the quality control lab equipment list and instruments used in the quality control department but not limit
- Principle of High-Performance Liquid Chromatography
- Principle of Gas Chromatography
- Principle of UV Visible spectrophotometer
- Principle of Infrared spectrophotometer
- Principle of Karl Fischer
- Principle of pH
- Principle of potentiometer
- Principle of polarimeter
- Principle of Thin layer chromatography
- Principle of Refractometer
1. Principle of High-Performance Liquid Chromatography (HPLC):
HPLC is separation technique of the components of mixture by using solid stationary phase and liquid mobile phase.
2. Principle of Gas chromatography (GC):
The principle of GC is as below;
GC is a separation technique is based on the principle of adsorption of gases or vapours of a liquid by an adsorbent.
3. Principle of UV visible spectrophotometer (UV visible):
The principle of UV visible spectroscopy is as below;
When a beam of monochromatic light is passes through the homogeneous absorbing medium, the rate of decrease in intensity of light is directly proportional to the concentration and path length of the cell.
4. Principle of Infrared spectrophotometer (IR spectroscopy):
The principle of IR spectroscopy is as below;
The infrared spectroscopy is vibrational energy level changes when IR radiation passes through the material.
5. Principle of Karl Fischer (KF):
The principle of Karl Fischer is as below;
The titrimetric determination of water is based on the quantitative reaction of water with anhydrous sulfur dioxide and iodine in the presence of suitable base.
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6. Principle of pH:
pH is nothing but the hydrogen ion present in the solution. Or the concentration of hydrogen ion in the solution.
The principle of pH is as below;
pH is to measure the electromotive force generated by the system of two electrodes, an indicator electrode whose potential depends on the concentration of hydrogen ion and a reference electrode with known potential.
7. Principle of potentiometer:
The principle of a potentiometer is as below;
When a steady current flows through a wire of uniform cross section the potential difference per unit length of the wire is constant through out the length of wire. Or potential difference across any two points of the wire is directly proportional to the length of the wire.
8. Principle of Polarimeter:
The polarimeter is used to detect the optically active property of the drug product.
The principle of polarimeter is as below;
Polarimeter measures the rotation polarized light as it passes through an optically active fluid.
9. Principle of Thin Layer chromatography (TLC):
The principle of Thin Layer Chromatography ( TLC) is as below;
TLC is separation technique in which solute are deprecated by dymanic differential migration process in a system consisting of stationary phase and mobile phase.
10. Principle of Refractometer:
The principle of the Refractometer is as below;
It is a refraction based on the speed of light that passes in the different mediums.
These are the 10 principles of Quality Control instruments. Quality control lab equipment list Which will help for the interview.
- HPLC Interview Question and Answers
- Gas Chromatography Interview questions and answers
- Karl Fischer Titration Interview Question and Answer
- Dissolution Interview Question and Answer
- How to Do Calibration of FTIR Spectrophotometer?
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