Preparation and standardization of potassium Hydroxide:
Here we will understand how to do preparation and standardization of potassium hydroxide (KOH) as per USP.
95% V/V Alcohol: Mix 95 ml of absolute alcohol into 5 ml of water.
Phenolphthalein Solution: Dissolve 1 g of phenolphthalein in 100ml of 95% alcohol.
Preparation of 1 N potassium hydroxide (KOH):
- Take 100 ml of volumetric flask.
- Dissolve 68 g of potassium hydroxide.
- Add freshly prepared saturated solution of barium hydroxide until no more precipitate forms.
- make up the volume to 950 ml.
- Allow it to stand overnight in a stoppered bottle.
- Decant the clear liquid or filter the solution in a tight polyolefin bottle.
For lower strength, the solution can be prepared as follows;
|Quantity of KOH in g||Addition of water in ml||Strength of KOH|
Standardization of 1 N KOH Solution:
- Dry the potassium biphthalate in 120°c for 2 hrs.
- Weigh previously crushed 5 g of potassium biphthalate in 75 ml of water.
- Add 2 drops of phenolphthalein solution.
- Titrate the solution with 1 N potassium hydroxide.
- The solution produces a permanent pink color.
Calculation formula of 1N KOH:
Normality of 1N KOH = ——————
0.20423 x V
W= Weight of potassium biphthalate in g
V= Volume of potassium hydroxide consumed in ml.
Preparation and standardization of potassium Hydroxide (KOH) in pharmaceuticals.
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